Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes.
Peter P SwobodaBara ErhayiemRachel KanAdam K McDiarmidPankaj GargTarique A MusaLaura E DobsonKlaus K WitteMark T KearneyJulian H BarthRamzi AjjanJohn P GreenwoodSven PleinPublished in: Cardiovascular diabetology (2018)
Ascending aortic distensibility measured by CMR is independently associated with poor glycaemic control and adverse cardiovascular events. Furthermore it may be reversible on treatment with RAAS inhibition. AAD is a promising marker of cardiovascular risk in asymptomatic patients with type 2 diabetes and has potential use as a surrogate cardiovascular endpoint in studies of novel hypoglycaemic agents. Clinical trials registration https://clinicaltrials.gov/ct2/show/NCT01970319.
Keyphrases
- cardiovascular events
- magnetic resonance
- type diabetes
- pulmonary artery
- clinical trial
- aortic dissection
- aortic valve
- coronary artery disease
- contrast enhanced
- cardiovascular disease
- left ventricular
- computed tomography
- image quality
- coronary artery
- magnetic resonance imaging
- pulmonary hypertension
- heart failure
- randomized controlled trial
- risk assessment
- pulmonary arterial hypertension
- human health
- phase ii
- adverse drug
- replacement therapy