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Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes.

Peter P SwobodaBara ErhayiemRachel KanAdam K McDiarmidPankaj GargTarique A MusaLaura E DobsonKlaus K WitteMark T KearneyJulian H BarthRamzi AjjanJohn P GreenwoodSven Plein
Published in: Cardiovascular diabetology (2018)
Ascending aortic distensibility measured by CMR is independently associated with poor glycaemic control and adverse cardiovascular events. Furthermore it may be reversible on treatment with RAAS inhibition. AAD is a promising marker of cardiovascular risk in asymptomatic patients with type 2 diabetes and has potential use as a surrogate cardiovascular endpoint in studies of novel hypoglycaemic agents. Clinical trials registration https://clinicaltrials.gov/ct2/show/NCT01970319.
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