Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

Colin ShepherdDongxing ZhuAndrew J SkeltonJennifer CombeHarrison ThreadgoldLinyi ZhuTonia L VincentPaul StuartLouise N ReynardJohn Loughlin

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2018)

The ALDH1A2 locus seems to increase the risk of hand OA through decreased expression of ALDH1A2 in joint tissues, with the effect dependent on rs12915901. These findings indicate a mechanism that may now be targeted to modulate OA risk.

Keyphrases

knee osteoarthritis
genome wide
poor prognosis
gene expression
dna methylation
binding protein
drug delivery