The nongenomic neuroprotective effects of estrogen, E2-BSA, and G1 following traumatic brain injury: PI3K/Akt and histopathological study.

Ladan AmirkhosraviMohammad KhaksariMojgan SanjariParisa Khorasani

Published in: Hormone molecular biology and clinical investigation (2024)

These findings indicated that PI3K/p-Akt pathway plays a critical role in mediating the salutary effects of estradiol on histopathological changes and neurological outcomes following TBI, suggesting that GPER and classic ERs are involved in regulating the expression of PI3K/p-Akt.

Keyphrases

signaling pathway
pi k akt
traumatic brain injury
cell proliferation
estrogen receptor
cell cycle arrest
poor prognosis
severe traumatic brain injury
binding protein
long non coding rna