Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.

Julius L Decano Enrico Maiorino Joan T Matamalas Sarvesh Chelvanambi Bart M Tiemeijer Yoshihiro Yanagihara Shin MukaiPrabhash Kumar JhaDiego Vinicius Santinelli Pestana Edwin D'Souza Mary Whelan Rile GeTakaharu AsanoAmitabh SharmaPeter Libby Sasha A Singh Elena Aikawa Masanori Aikawa

Published in: Circulation (2023)

We characterized 2 clusters of macrophages in atherosclerosis and combined our cellular data with a cell-signature drug library to identify a novel compound that targets a subset of macrophages in atherosclerosis. Our approach is a precision medicine strategy to identify new drugs that target atherosclerosis and other inflammatory diseases.

Keyphrases

cardiovascular disease
single cell
endothelial cells
oxidative stress
cell therapy
drug induced
small molecule
genome wide
adverse drug
big data
stem cells
type diabetes
dna methylation
gene expression
induced pluripotent stem cells
transcription factor
machine learning
artificial intelligence