Characterization and Management of Stable Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation.
Sofia SammartinoGiulia LaterraThomas PilgrimIgnacio J Amat-SantosOle De BackerWon Keun KimHenrique Barbosa RibeiroFrancesco SaiaMatjaž BuncDidier TchetchePhilippe GarotFlavio Luciano RibichiniDarren MylotteFrancesco BurzottaYusuke WatanabeFrancesco BedogniTullio TesorioTobias RheudeGennaro SardellaMarco TocciAnna FranzoneRoberto ValvoMikko SavontausHendrik WienemannItalo PortoCaterina GandolfoAlessandro IadanzaAlessandro Santo BortoneMarkus MachAzeem LatibLuigi BiascoMaurizio TaramassoFederico De MarcoValentina FrittittaElena DipietroClaudia ReddavidOrazio StrazzieriSilvia MottaAlessandro ComisChiara MelfaMariachiara CalìCarmelo SgroiMohamed Abdel-WahabGiulio Giuseppe StefaniniCorrado TamburinoMarco BarbantiGiuliano CostaPublished in: Journal of clinical medicine (2024)
Background/Objectives : To date, data regarding the characteristics and management of obstructive, stable coronary artery disease (CAD) encountered in patients undergoing transcatheter aortic valve implantation (TAVI) are sparse. The aim of the study was to analyze granular details, treatment, and outcomes of patients undergoing TAVI with obstructive, stable CAD from real-world practice. Methods : REVASC-TAVI (Management of myocardial REVASCularization in patients undergoing Transcatheter Aortic Valve Implantation with coronary artery disease) is an investigator-initiated, multicenter registry, which collected data from patients undergoing TAVI with obstructive stable CAD found during the pre-TAVI work-up. Results : A total of 2025 patients from 30 centers worldwide with complete follow-up were included in the registry. Most patients had single-vessel CAD (56.1%). An involvement of proximal coronary tracts was detected in 62.5% of cases, with 12.0% of patients having CAD in left main (LM). Most patients received percutaneous coronary intervention (PCI) (n = 1617, 79.9%), especially those with proximal CAD (90.4%). At 2 years, the rates of all-cause death [Kaplan-Meier (KM) estimates 20.1% vs. 18.8%, p log-rank = 0.86] and of the composite of all-cause death, stroke, myocardial infarction, and rehospitalization for heart failure (KM estimates 29.7% vs. 27.5%, p log-rank = 0.82) did not differ between patients undergoing PCI and those who were not. Conclusions : Patients undergoing TAVI with obstructive CAD more commonly had a single-vessel disease and an involvement of proximal coronary tracts. They were commonly treated with PCI, with similar outcomes compared to those treated conservatively.
Keyphrases
- coronary artery disease
- transcatheter aortic valve implantation
- aortic stenosis
- patients undergoing
- percutaneous coronary intervention
- ejection fraction
- aortic valve
- aortic valve replacement
- heart failure
- coronary artery bypass grafting
- end stage renal disease
- cardiovascular events
- transcatheter aortic valve replacement
- acute myocardial infarction
- newly diagnosed
- st segment elevation myocardial infarction
- st elevation myocardial infarction
- left ventricular
- prognostic factors
- atrial fibrillation
- chronic kidney disease
- acute coronary syndrome
- antiplatelet therapy
- clinical trial
- metabolic syndrome
- healthcare
- machine learning
- skeletal muscle
- insulin resistance
- big data
- blood brain barrier
- cross sectional
- artificial intelligence
- deep learning