Long Non-Coding RNAs in Obesity-Induced Cancer.
Mabel Yin-Chun YauLu XuChien-Ling HuangChi-Ming WongPublished in: Non-coding RNA (2018)
Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers. We hope this review can serve as an inspiration to scientists to further explore the regulatory roles of lncRNAs in the development of obesity-induced cancers. Those findings will be fundamental in the development of effective therapeutics or interventions to combat this life-threatening adverse effect of obesity.
Keyphrases
- metabolic syndrome
- weight loss
- insulin resistance
- type diabetes
- high glucose
- long non coding rna
- diabetic rats
- high fat diet induced
- weight gain
- poor prognosis
- drug induced
- bariatric surgery
- emergency department
- adipose tissue
- body mass index
- small molecule
- oxidative stress
- transcription factor
- endothelial cells
- physical activity
- climate change
- lymph node metastasis
- stress induced
- genome wide identification
- obese patients
- genome wide analysis
- human health