A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57.

Rachelle E IrwinSara-Jayne ThursbyMiroslava OndičováKristina PentievaHelene McNultyRebecca C RichmondAoife CaffreyDiane J Lees-MurdockMarian McLaughlinTony CassidyMatthew SudermanCaroline L ReltonColum P Walsh

Published in: Clinical epigenetics (2019)

These results strengthen the link between folic acid supplementation during later pregnancy and epigenetic changes and identify a novel mechanism for regulation of ZFP57. This trial was registered 15 May 2013 at www.isrctn.com as ISRCTN19917787.

Keyphrases

dna methylation
preterm birth
pregnancy outcomes
randomized controlled trial
study protocol
gene expression
clinical trial
phase iii
genome wide
pregnant women
placebo controlled