Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling.
Degang SongXiaomin ChenNa ZhouYi YuanShuo GengCong ZhangZhe ZhaoXingran WangXinran BaoXifa LanXiang-Jian ZhangPublished in: Journal of translational medicine (2023)
LIPUS induced a neurorestorative stimulation against VaD may be through upregulation of the hippocampal Fndc5/irisin levels. Hippocampal Fndc5/irisin signaling might be a promising strategic target for VaD.
Keyphrases
- cerebral ischemia
- cognitive impairment
- temporal lobe epilepsy
- subarachnoid hemorrhage
- mild cognitive impairment
- magnetic resonance imaging
- cell proliferation
- poor prognosis
- drug induced
- brain injury
- blood brain barrier
- high fat diet induced
- computed tomography
- endothelial cells
- insulin resistance
- ultrasound guided