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Cortical Spreading Depolarization, Blood Flow, and Cognitive Outcomes in a Closed Head Injury Mouse Model of Traumatic Brain Injury.

Nathaniel MosleyJoon Y ChungGina JinMaria A FranceschiniMichael J WhalenDavid Y Chung
Published in: Neurocritical care (2022)
The data suggest that a lower baseline cerebral blood flow prior to injury may contribute to the occurrence of a CSD. Furthermore, a CSD at the time of injury can be associated with worse cognitive outcome under the appropriate experimental conditions in a mouse CHI model of TBI.
Keyphrases
  • traumatic brain injury
  • blood flow
  • cerebral blood flow
  • mouse model
  • electronic health record
  • type diabetes
  • big data
  • machine learning
  • skeletal muscle
  • data analysis
  • mild traumatic brain injury