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The relationship between infliximab concentrations, antibodies to infliximab and disease activity in Crohn's disease.

Niels Vande CasteeleReena KhannaBarrett G LevesqueLarry StittG Y ZouSharat SinghSteve LocktonScott HauensteinLinda OhrmundGordon R GreenbergPaul J RutgeertsAnn GilsWilliam J SandbornSéverine VermeireBrian G Feagan
Published in: Gut (2014)
The development of ATI increases the probability of active disease even at low concentrations and in the presence of a therapeutic concentration of drug during infliximab maintenance therapy. Evaluation of strategies to prevent ATI formation, including therapeutic drug monitoring with selective infliximab dose intensification, is needed.
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