LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice.
Devadoss J SamuvelYasodha KrishnasamyLi LiJohn J LemastersC James ChouZhi ZhongPublished in: RPS pharmacy and pharmacology reports (2023)
This novel HDACi protects against IRI most likely by epigenetic upregulation of antioxidant proteins and post-translational modifications of NFκB thus inhibiting iNOS expression and inflammatory responses.
Keyphrases
- histone deacetylase
- oxidative stress
- poor prognosis
- signaling pathway
- induced apoptosis
- long non coding rna
- dna damage
- dna methylation
- diabetic rats
- cerebral ischemia
- gene expression
- pi k akt
- ischemia reperfusion injury
- acute myocardial infarction
- high fat diet induced
- cell proliferation
- lps induced
- nitric oxide synthase
- anti inflammatory
- immune response
- heart failure
- percutaneous coronary intervention
- acute coronary syndrome
- subarachnoid hemorrhage
- inflammatory response
- brain injury
- heat shock
- nuclear factor
- left ventricular