Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development.
Paola Fernandes PansiniIsabella Bittencourt do ValleThabata Coeli Dias DamascenoPriscila Marinho de AbreuAnna Clara Gregório CóRossana Verónica Mendoza LópezJeferson LenziRicardo Mai RochaEvandro Duccini SouzaMaria Paula CuradoHisham MehannaPaul NankivellJosé Roberto Vasconcelos de PodestáSandra Lucia Ventorin Von ZeidlerPublished in: Head and neck pathology (2021)
To evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2A (CDKN2A), epidermal growth factor receptor (EGFR), polo like kinase 1 (PLK1), p63, p40 (Δnp63 isoform), cyclin D1 (CCND1) and BCL2 apoptosis regulator (BCL2) proteins could predict malignant transformation. Different tissue segments (tumor adjacent epithelium; dysplasia and tumor) from a total of 109 patients were analyzed by immunohistochemistry. An increased expression of survivin (p < 0.001), PLK1 (p = 0.001), and p63 (p < 0.001) in parallel to reduced immunostaining of p40 (p < 0.001) and BCL2 (p = 0.029) was observed among the tissue segments analyzed. Our study revealed that survivin, PLK1, p63, p40 and BCL2 play a role in oral tumorigenesis and represent promising biomarkers able to recognize mesenchymal phenotype induction in the transition from nonmalignant cells to tumor cells. These results reveals critical interaction between survivin, PLK1, p63, p40 promising proteins during invasive carcinoma development.
Keyphrases
- epidermal growth factor receptor
- cell cycle arrest
- tyrosine kinase
- cell death
- end stage renal disease
- advanced non small cell lung cancer
- pi k akt
- induced apoptosis
- ejection fraction
- chronic kidney disease
- cell cycle
- newly diagnosed
- oxidative stress
- small cell lung cancer
- peritoneal dialysis
- stem cells
- endoplasmic reticulum stress
- poor prognosis
- bone marrow
- single cell
- patient reported outcomes
- single molecule
- binding protein