Impact of the menstrual cycle on commercial prognostic gene signatures in oestrogen receptor-positive primary breast cancer.

Ben P HaynesGene SchusterRichard BuusAnastasia AlatakiOphira GinsburgLe Hong QuangPham Thi HanPham Hong KhoaNguyen Van DinhTa Van ToMark ClemonsChris HolcombeCaroline OsborneAbigail EvansAnthony SkeneMark SibberingClare RogersSiobhan LawsLubna NoorMaggie Chon U CheangSusan J CleatorIan E SmithMitchell Dowsett

Published in: Breast cancer research and treatment (2021)

There are significant changes during the menstrual cycle in the expression of some of the genes and gene module scores comprising the RS, ROR and EP/EPclin scores. These did not affect any of the prognostic scores in a systematic fashion, but there was substantial variability in paired measurements.

Keyphrases

genome wide
genome wide identification
copy number
poor prognosis
dna methylation
genome wide analysis
transcription factor
gene expression
bioinformatics analysis