A Monoclonal Antibody Against β1 Integrin Inhibits Proliferation and Increases Survival in an Orthotopic Model of High-Grade Meningioma.

Fares NigimJuri KiyokawaAlessandra GurtnerYoichiro KawamuraLingyang HuaEkkehard M KasperPriscilla K BrastianosDaniel P CahillSamuel D RabkinRobert L MartuzaW Shawn CarbonellHiroaki Wakimoto

Published in: Targeted oncology (2020)

β1 Integrin may be a therapeutic target in HGMs, and further preclinical and clinical development of OS2966 for HGM therapy is warranted.

Keyphrases

monoclonal antibody
high grade
low grade
cell adhesion
cell migration
cell therapy
free survival
optic nerve
optical coherence tomography