Effect of Mycobacterium leprae on neurotrophins expression in human Schwann cells and mouse sciatic nerves.
Maria Renata Sales NogueiraNádia Ghinelli AmôrLetícia Baccaro MichellinMilton Cury FilhoPatrícia Sammarco RosaAna Carla Pereira LatiniLuciana Silva RodriguesRobertha Mariana Rodrigues LemesFlavio Alves LaraMaria Cristina Vidal PessolaniPublished in: Memorias do Instituto Oswaldo Cruz (2020)
Our in vitro results showed a trend to decline in NGF and BDNF mRNA in ML-treated hSC, compared to controls. The immunodetection of BDNF and NT-4 was significantly downregulated in ML-treated hSC. Conversely, ML-infected mice demonstrated upregulation of NT-3, compared to non-infected animals. Our findings indicate that ML may be involved in neurotrophins regulation, suggesting that a pathogen-related imbalance of these growth factors may have a role in the neural impairment of leprosy.
Keyphrases
- poor prognosis
- induced apoptosis
- endothelial cells
- binding protein
- peripheral nerve
- cell cycle arrest
- stress induced
- mycobacterium tuberculosis
- cell proliferation
- signaling pathway
- long non coding rna
- growth factor
- neuropathic pain
- induced pluripotent stem cells
- candida albicans
- newly diagnosed
- adipose tissue
- spinal cord injury
- insulin resistance
- spinal cord
- metabolic syndrome
- pi k akt