Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma.
Li ChenMoli HuangJasmine PlummerJian PanYan Yi JiangQian YangTiago Chedraoui SilvaNicole GullStephanie ChenLing Wen DingOmer AnHenry YangYulan ChengJonathan W SaidNgan DoanWinand Nm DinjensKevin M WatersRichard TuliSimon A GaytherSamuel J KlempnerBenjamin P BermanStephen J MeltzerDe-Chen LinH Phillip KoefflerPublished in: Gut (2019)
By establishing cancer-specific and subtype-specific features of the EAC epigenome, our findings promise to transform understanding of the transcriptional dysregulation and addiction of EAC, while providing molecular clues to develop novel therapeutic modalities against this malignancy.