Evaluating early intervention in smoldering myeloma clinical trials: a systematic review.
Apoorva KakkilayaAaron TrandoEdward Robert Scheffer CliffHira MianSamer Al HadidiMuhammad AzizAaron M GoodmanAh-Reum JeongWade L SmithAmar H KelkarDavid A Russler-GermainNikita MehraRajshekhar ChakrabortyMorie A GertzGhulam Rehman MohyuddinPublished in: The oncologist (2024)
In this systematic review of all prospective interventional clinical trials in SMM, we found significant variability in trial design, including randomization status, primary endpoints, and types of intervention used. Despite the statistical limitations, comparison of treatment regimens revealed no compelling evidence that the treatment is more effective when introduced early in SMM compared to NDMM.