Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway.

Lianbo ShaoYihuan ChenJingjing LiJingfan ChaoZiying YangYinglong DingHan ShenYueqiu ChenZhen-Ya Shen

Published in: Stem cells international (2023)

-sEVs promote HUVEC tube formation and migration by transferring miR-214 into recipient cells, inhibiting Sufu expression, and activating the hedgehog pathway. Hypoxia-induced vesicle modification is a feasible way to restore heart function after myocardial infarction.

Keyphrases

long non coding rna
cell proliferation
poor prognosis
signaling pathway
induced apoptosis
long noncoding rna
endothelial cells
heart failure
mesenchymal stem cells
cell cycle arrest
left ventricular
bone marrow
cell death
endoplasmic reticulum stress
stem cells
binding protein
cell therapy