Asymmetric Construction of Fluoroalkyl Tertiary Alcohols through a Three-Component Reaction of (Bpin)2, 1,3-Enynes, and Fluoroalkyl Ketones Catalyzed by a Copper(I) Complex.

An asymmetric three-component reaction of Bis(pinacolato)diboron ((BPin)2), 1,3-enynes, and fluoroalkyl ketones was carried out by using a copper(I)-Ph-BPE complex as the catalyst, which afforded a series of chiral fluoroalkyl diols in good to high yield, good to high diastereoselectivity, and high enantioselectivity after an oxidative workup. The reaction exhibits advantages that include a broad substrate scope, high functional group compatibility, high stereoselectivity, and an easy reaction protocol. The synthetic utility of the reaction was showcased by several transformations.