Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice.
Stephan SachsLili NiuPhilipp E GeyerSigrid JallMaximilian KleinertAnnette FeuchtingerKerstin StemmerMarkus BrielmeierBrian FinanRichard D DiMarchiMatthias H TschöpNicolai J Wewer AlbrechtsenMatthias MannTimo Dirk MüllerSusanna M HofmannPublished in: Diabetes, obesity & metabolism (2020)
We herein show that a recently developed unimolecular GLP-1/GIP co-agonist is more efficient in improving metabolic disease than either mono-agonist in both sexes. PPP led to the identification of a sex-independent protein panel with the potential to monitor non-invasively the treatment efficacies on metabolic function of this clinically advancing GLP-1/GIP co-agonist.