SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes.
Xiaoqian WuHuan LiuAlan BrooksSuowen XuJinque LuoRebbeca SteinerDeanne M MickelsenChristine S MoravecAlexis D JeffreyEric M SmallZheng Gen JinPublished in: Circulation research (2022)
The impairment of endothelial SIRT6 expression links diabetes to HFpEF through the alteration of FA transport across the endothelial barrier. Genetic and pharmacological strategies that restored endothelial SIRT6 function in mice with diabetes alleviated experimental HFpEF by limiting FA uptake and improving cardiac metabolism, thus warranting further clinical evaluation.