Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients.

Vatsalya VatsalyaMing SongMelanie L SchwandtMatthew C CaveShirish S BarveDavid T GeorgeVijay A RamchandaniCraig J McClain

Published in: Alcoholism, clinical and experimental research (2016)

Measures of heavy drinking, TD90 and HDD90, predicted changes in liver injury. Changes in the ω-3 and ω-6 FA levels and the ω-6:ω-3 ratio showed a pro-inflammatory shift in patients with biochemical liver injury with a significant effect in females. Changes in FAs involved in the inflammatory state may represent one mechanism for liver inflammation/injury in response to heavy alcohol drinking.

Keyphrases

liver injury
drug induced
alcohol consumption
end stage renal disease
fatty acid
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors