Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence.
Raoul Charles CoombesKaren PageRaheleh SalariRobert K HastingsAnne C ArmstrongSamreen AhmedSimak AliSusan CleatorLaura KennyJustin StebbingMark J RutherfordHimanshu SethiAnna BoydellRyan SwenertonDaniel Fernandez-GarciaKelly L T GleasonKatie GoddardDavid S GutteryZoe J AssafHsin-Ta WuPrashanthi NatarajanDavid A MooreLindsay PrimroseScott DashnerAntony S TinMustafa BalciogluRamya SrinivasanSvetlana V ShchegrovaAlexander OlsonDina HafezPaul BillingsAlexey AleshinFarah RehmanBradley J ToghillAllison HillsMaggie C LouieCheng-Ho Jimmy LinBernhard G ZimmermannJacqueline A ShawPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
This study demonstrates that patient-specific ctDNA analysis can be a sensitive and specific approach for disease surveillance for patients with breast cancer. More importantly, earlier detection of up to 2 years provides a possible window for therapeutic intervention.