MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse.

Xiaolin WangYanfang YangYuanli ChenYajun DuanJihong HanXiao Xiao Yang

Published in: Molecular biology reports (2022)

Our findings revealed inhibition of ERK1/2 can significantly increase ADH1 expression, indicating MEK1/2 inhibitors may possess potential application in alcohol-related diseases.

Keyphrases

poor prognosis
pi k akt
signaling pathway
cell proliferation
alcohol consumption