Heavy-atom-free triplet benzothiophene-fused BODIPY derivatives for lipid droplet-specific biomaging and photodynamic therapy.
Weibin BuChangjiang YuYingxiu ManJiazhu LiQinghua WuShuangying GuiYaxiong WeiLijuan JiaoErhong HaoPublished in: Chemical communications (Cambridge, England) (2024)
The twist fusion of a benzothiophene group and the introduction of a 4-methyloxystyryl donor group to the BODIPY core resulted in large spin-orbit coupling values and smaller singlet-triplet energy gaps for the novel infrared absorbed photosensitizers named BSBDP. They show a high reactive oxygen species efficiency exceeding 69% and a fluorescence quantum yield of 23% and are successfully applied in imaging-guided photodynamic therapy in vitro and in vivo .
Keyphrases
- photodynamic therapy
- energy transfer
- reactive oxygen species
- fluorescence imaging
- fluorescent probe
- living cells
- room temperature
- molecular dynamics
- quantum dots
- single molecule
- high resolution
- density functional theory
- epithelial mesenchymal transition
- single cell
- high throughput
- fatty acid
- electron transfer
- mass spectrometry