Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β-Hydroxyketones.

Simon HilkerDaniels PosevinsC Rikard Unelius Jan E Bäckvall

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)

Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α-substituted β-hydroxyketones (β-HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α-substituted β-oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.

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