Upregulation of phosphodiesterase 7A leads to the downregulation of cAMP-PKA-CREB-BDNF signaling and neuroinflammation in the hippocampus and contributes to concurrent chronic pain and depression in two mouse models.

Shi-Cai ChenYan-Han ChenYan SongShu-Hua ZongMing-Xia WuWei WangHao WangFeng ZhangYan-Meng ZhouHai-Yang YuHan-Ting ZhangFang-Fang Zhang

Published in: The international journal of neuropsychopharmacology (2024)

Hippocampal PDE7A mediated concurrent chronic pain and depression in both mouse models by inhibiting cAMP-PKA-CREB-BDNF signaling Inhibiting PDE7A or activating cAMP-PKA-CREB-BDNF signaling are potential strategies to treat concurrent chronic pain and depression.

Keyphrases

chronic pain
signaling pathway
mouse model
depressive symptoms
pain management
locally advanced
sleep quality
binding protein
cell proliferation
stress induced
traumatic brain injury
poor prognosis
risk assessment
physical activity
human health
inflammatory response