Alginate Microsponges as a Scaffold for Delivery of a Therapeutic Peptide against Rheumatoid Arthritis.
Daniela AriaudoFrancesca CavalieriAntonio RinaldiAna AguileraMatilde LopezHilda Garay PerezAriel FelipeMaria Del Carmen DominguezOdalys RuizGillian MartinezMariano VenanziPublished in: Nanomaterials (Basel, Switzerland) (2023)
The quest for biocompatible drug-delivery devices that could be able to open new administration routes is at the frontier of biomedical research. In this contribution, porous polysaccharide-based microsponges based on crosslinked alginate polymers were developed and characterized by optical spectroscopy and nanoscopic microscopy techniques. We show that macropores with a size distribution ranging from 50 to 120 nm enabled efficient loading and delivery of a therapeutic peptide (CIGB814), presently under a phase 3 clinical trial for the treatment of rheumatoid arthritis. Alginate microsponges showed 80% loading capacity and sustained peptide release over a few hours through a diffusional mechanism favored by partial erosion of the polymer scaffold. The edible and biocompatible nature of alginate polymers open promising perspectives for developing a new generation of polysaccharide-based carriers for the controlled delivery of peptide drugs, exploiting alternative routes with respect to intravenous administration.
Keyphrases
- rheumatoid arthritis
- tissue engineering
- clinical trial
- drug delivery
- high resolution
- minimally invasive
- wound healing
- disease activity
- drug release
- photodynamic therapy
- interstitial lung disease
- ionic liquid
- randomized controlled trial
- high throughput
- low dose
- cancer therapy
- phase ii
- metal organic framework
- solid state