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Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action.

Wamidh H TalibMedia Mohammed BabanMais Fuad BulbulEsraa Al-ZaidaneenAya AllanEiman Wasef Al-RousanRahaf Hamed Yousef AhmadHeba K AlshaeriMoudi M AlasmariDouglas Law
Published in: International journal of molecular sciences (2024)
Cancer is characterized by uncontrolled cell proliferation and the dysregulation of numerous biological functions, including metabolism. Because of the potential implications of targeted therapies, the metabolic alterations seen in cancer cells, such as the Warburg effect and disruptions in lipid and amino acid metabolism, have gained attention in cancer research. In this review, we delve into recent research examining the influence of natural products on altered cancer metabolism. Natural products were selected based on their ability to target cancer's altered metabolism. We identified the targets and explored the mechanisms of action of these natural products in influencing cellular energetics. Studies discussed in this review provide a solid ground for researchers to consider natural products in cancer treatment alone and in combination with conventional anticancer therapies.
Keyphrases
  • papillary thyroid
  • cell proliferation
  • lymph node metastasis
  • childhood cancer
  • signaling pathway
  • working memory
  • fatty acid
  • cell cycle
  • climate change