Tirzepatide suppresses palatable food intake by selectively reducing preference for fat in rodents.

Caroline E GeislerMeghan P AntonellisWolfgang TrumbauerJennifer A MartinTamer CoskunRicardo J SammsMatthew R Hayes

Published in: Diabetes, obesity & metabolism (2022)

Decreasing preference for high-caloric, high-fat foods is a powerful action of GLP-1R and dual GIPR/GLP-1R agonist therapeutics, which may contribute to the weight loss success of these drugs.

Keyphrases

weight loss
bariatric surgery
adipose tissue
roux en y gastric bypass
signaling pathway
small molecule
gastric bypass
fatty acid
skeletal muscle
physical activity
glycemic control