Enrichment reveals extensive integration of hepatitis B virus DNA in hepatitis delta-infected patients.
Johan RinglanderLucia Gonzales StrömbergJoakim B StenbäckMaria E AnderssonSanna AbrahamssonCatarina SkoglundMaria CastedalSimon B LarssonGustaf E RydellMagnus LindhPublished in: The Journal of infectious diseases (2024)
The results suggest that HBV DNA integrates in a large proportion of hepatocytes, and that the HBsAg output from these integrations vary >100-fold depending on clone size and expression rate. A small part of the integrations seems to determine the serum levels of HBsAg and HDV RNA in HBV/HDV co-infected patients with liver cirrhosis.