Variants of concern are overrepresented among post-vaccination breakthrough infections of SARS-CoV-2 in Washington State.

Abbye E McEwenSeth CohenChloe Bryson-CahnCatherine LiuSteven A PergamJohn LynchAdrienne SchippersKathy StrandEstella WhimbeyNandita S ManiAllison J ZelikoffVanessa A MakarewiczElizabeth R BrownShah A Mohamed BakhashNoah R BakerJared CastorRobert J LivingstonMeei-Li HuangKeith R JeromeAlexander L GreningerPavitra Roychoudhury

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOC) and had a median Ct of 20.2 (IQR=17.1-23.3). When compared to 5174 contemporaneous samples sequenced in our laboratory, VOC were significantly enriched among breakthrough infections (p < .05).

Keyphrases

sars cov
copy number
computed tomography
magnetic resonance imaging
gene expression
image quality
positron emission tomography
dna methylation
genome wide
pet ct