Chemotherapy-induced fatigue is associated with changes in gene expression in the peripheral blood mononuclear cell fraction of patients with locoregional breast cancer.
Barbara Bonaparte Ribas de AlcântaraFelipe Melo CruzFernando Luiz Affonso FonsecaBeatriz da Costa Aguiar Alves ReisMatheus Moreira PerezPatricia VarelaJoão Bosco PesqueroDaniel de Iracema Gomes CuberoClaudia Vaz De Melo SetteAuro Del GiglioPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2018)
CIF induces specific changes in gene expression in the PBMNC of LRBC patients. Some of these changes, such as downregulation of NCAN expression, may reflect direct effects of chemotherapy since they are also observed in the controls. Furthermore, CIF may involve downregulation of skeletal muscle genes (RHOBT1, DUSP18) and immune systems (RAETG1), whereas NCAN downregulation may underlie the adverse cognitive effects of chemotherapy.
Keyphrases
- gene expression
- chemotherapy induced
- peripheral blood
- skeletal muscle
- cell proliferation
- signaling pathway
- dna methylation
- end stage renal disease
- ejection fraction
- poor prognosis
- locally advanced
- newly diagnosed
- genome wide
- emergency department
- prognostic factors
- squamous cell carcinoma
- stem cells
- type diabetes
- cell therapy
- radiation therapy
- patient reported outcomes
- sleep quality
- bone marrow
- young adults
- binding protein