TET-mediated hydroxymethylcytosine at the Pparγ locus is required for initiation of adipogenic differentiation.

Yoon Jung ParkJ H ParkC WeigelD B LiesenfeldD WeichenhanC PlassD-G SeoA M LindrothY J Park

Published in: International journal of obesity (2005) (2017)

TET proteins, particularly TET2, were required for adipogenesis by modulating DNA methylation at the Pparγ locus, subsequently by inducing Pparγ gene expression.

Keyphrases

dna methylation
gene expression
insulin resistance
genome wide
fatty acid
signaling pathway
metabolic syndrome
type diabetes
adipose tissue
copy number