Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury.

Elissa M MilfordLara MeitalAnna KuballaMichael C ReadeFraser D Russell

Published in: Intensive care medicine experimental (2022)

and upregulation of SDC-4 production. Further studies to examine whether FTY720 or another S1PR agonist might have EG-protective effects under different conditions are warranted, as are investigations seeking the mechanism of EG protection conferred by FFP in this experimental model.

Keyphrases

endothelial cells
multiple sclerosis
high glucose
poor prognosis
mental health
vascular endothelial growth factor
cell proliferation
case control
signaling pathway
long non coding rna