Impact of LAG-3/FGL1 pathway on immune evasive contexture and clinical outcomes in advanced urothelial carcinoma.

Takashi Yoshida Takahiro NakamotoNaho AtsumiChisato OheTakeshi SanoYoshiki YasukochiKoji TsutaHidefumi Kinoshita

Published in: Journal for immunotherapy of cancer (2024)

LAG-3 expression and high FGL1 coexpression are important predictive factors of adverse oncological outcomes related to the presence of immunosuppressive contextures. These findings are hypothesis-generating, warranting further mechanistic and clinical studies aimed to evaluate LAG-3/FGL1 blockade in UC.

Keyphrases

poor prognosis
radical prostatectomy
network analysis
type diabetes
emergency department
insulin resistance
weight loss
adverse drug
drug induced