Login / Signup

Covariate-constrained randomization in cluster randomized 2x2 factorial trials: Application to a diabetes prevention study.

Juned SiddiqueZhehui LiMatthew J O'Brien
Published in: Research square (2024)
CR should be used instead of simple randomization when performing factorial CRTs to avoid highly imbalanced designs and to obtain more precise inferences. Except when there are a small number of clusters, cluster-level covariates should be included in the analysis model to increase power and maintain coverage and Type 1 error rates at their nominal levels.
Keyphrases
  • type diabetes
  • cardiovascular disease
  • double blind
  • open label
  • placebo controlled
  • phase iii
  • randomized controlled trial
  • clinical trial
  • adipose tissue
  • affordable care act
  • insulin resistance
  • health insurance