Quantification of disease progression in spinal muscular atrophy with muscle MRI-a pilot study.
Louise A M OttoMartijn FroelingRuben P A van EijkFay-Lynn AsselmanRenske WadmanInge CuppenJeroen HendrikseW-Ludo van der PolPublished in: NMR in biomedicine (2021)
Longitudinal imaging data show slow disease progression in skeletal muscle of the thigh of (young-) adult patients with SMA despite stable strength and motor function scores. Quantitative muscle imaging demonstrates potential as a biomarker for disease activity and monitoring of therapy response.
Keyphrases
- skeletal muscle
- disease activity
- high resolution
- rheumatoid arthritis
- systemic lupus erythematosus
- young adults
- rheumatoid arthritis patients
- ankylosing spondylitis
- insulin resistance
- magnetic resonance imaging
- juvenile idiopathic arthritis
- type diabetes
- magnetic resonance
- electronic health record
- contrast enhanced
- mass spectrometry
- metabolic syndrome
- mesenchymal stem cells
- human health
- bone marrow
- deep learning
- diffusion weighted imaging