Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.
Christina E ToomeyWendy E HeywoodJames R EvansJoanne LachicaSarah N PresseySandrine C FotiMesfer Al ShahraniKarishma D'SaIain P HargreavesSimon J R HealesMichael OrfordClaire TroakesJohannes AttemsEllen GelpiMiklos PalkovitsTammaryn LashleySteve M GentlemanTamas ReveszKevin A MillsSonia GandhiPublished in: Acta neuropathologica communications (2022)
Our study provides an in-depth regional profile of the proteome at different stages of PD, and highlights that mitochondrial dysfunction is detectable prior to neuronal loss, and alpha-synuclein fibril deposition, suggesting that mitochondrial dysfunction is one of the key drivers of early disease.