Risk-Reducing Salpingo-Oophorectomy and Breast Cancer Risk Reduction in the Gynecologic Oncology Group Protocol-0199 (GOG-0199).

Phuong L MaiAustin Miller Mitchell H GailSteven SkatesKaren LuMark E ShermanOlga B IoffeGustavo RodriguezDavid E CohnJohn BoggessThomas RutherfordNoah D KauffJanet S RaderKelly-Anne PhillipsPaul A DiSilvestroAlexander B OlawaiyeMildred R RidgwayMark H GreeneMarion PiedmonteJoan L Walker

Published in: JNCI cancer spectrum (2019)

These data suggest that RRSO might be associated with reduced breast cancer incidence among women with a BRCA1/2 pathogenic variant, although the effect, if present, is small. This evolving evidence warrants a thorough discussion regarding the impact of RRSO on breast cancer risk with women considering this intervention.

Keyphrases

breast cancer risk
randomized controlled trial
palliative care
electronic health record
risk factors
endometrial cancer
type diabetes
machine learning
metabolic syndrome
pregnant women
skeletal muscle
young adults
smoking cessation
cervical cancer screening