Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system.
Razan WafaiElizabeth D WilliamsEmma de SouzaPeter T SimpsonAmy E McCart ReedJamie R KutasovicMark WalthamCameron E SnellTony BlickErik W ThompsonHonor J HugoPublished in: Breast cancer research : BCR (2020)
Our data suggest that despite an increase in ITGA2 and ITGB1 gene expression in the EMT exhibited by EDW01 PDX over multiple generations, this pathway may not necessarily drive the EMT process.