Association between DNA methylation levels in brain tissue and late-life depression in community-based participants.

Anke HülsChloe RobinsKaren N ConneelyPhilip Lawrence De JagerDavid A BennettMichael P Epstein Thomas S Wingo Aliza P Wingo

Published in: Translational psychiatry (2020)

We identified altered methylation in the YOD1, UGT8, FNDC3B, and SLIT2 loci as new epigenetic factors associated with late-life MDD. Furthermore, our study highlights the sex-specific molecular heterogeneity of MDD.

Keyphrases

dna methylation
genome wide
major depressive disorder
gene expression
single cell
white matter
copy number
bipolar disorder
sleep quality
physical activity
genome wide association study
brain injury
genome wide association