Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study.
Lauren C ShuffreySantiago MoralesMelanie H JacobsonMichelle Bosquet EnlowAkhgar GhassabianAmy E MargolisMaristella LucchiniKecia N CarrollRosa M CrumDana DabeleaArielle DeutschWilliam P FiferBrandon GoldsonChristine W HockettW Alex MasonLisette T JacobsonThomas G O'ConnorNicolò PiniYael RayportAyesha SaniaLeonardo TrasandeRosalind J WrightSeonjoo LeeCatherine Monknull nullPublished in: Child development (2023)
This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental influences on Child Health Outcomes (ECHO) Program from 2009-2021. GDM, prenatal, and postnatal maternal depressive symptoms were each associated with increased child externalizing and internalizing problems. GDM was associated with increased autism behaviors only among children exposed to perinatal maternal depressive symptoms above the median level. Stratified analyses revealed a relation between GDM and child outcomes in males only.
Keyphrases
- depressive symptoms
- mental health
- pregnant women
- pregnancy outcomes
- birth weight
- social support
- magnetic resonance
- autism spectrum disorder
- sleep quality
- preterm infants
- young adults
- human health
- computed tomography
- magnetic resonance imaging
- quality improvement
- machine learning
- risk assessment
- big data
- physical activity
- type diabetes
- diffusion weighted
- adipose tissue
- metabolic syndrome
- weight gain
- electronic health record
- contrast enhanced
- gestational age
- climate change