The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas.
Ines Garces de Los Fayos AlonsoHuan-Chang LiangSuzanne D TurnerSabine LaggerOlaf MerkelLukas KennerPublished in: Cancers (2018)
The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma.
Keyphrases
- transcription factor
- hodgkin lymphoma
- cell death
- dna binding
- binding protein
- healthcare
- nuclear factor
- poor prognosis
- small molecule
- protein protein
- multidrug resistant
- genome wide identification
- gene expression
- signaling pathway
- mesenchymal stem cells
- amino acid
- diffuse large b cell lymphoma
- stem cells
- papillary thyroid
- squamous cell
- oxidative stress
- immune response
- bone marrow
- inflammatory response
- heat shock