DROSHA but not DICER is required for human haematopoietic stem cell function.
Karen GuCarina WalpoleShayarana GooneratneXin LiuOscar L HaighKristen J RadfordMark M W ChongPublished in: Clinical & translational immunology (2022)
A miRNA-independent function of DROSHA is critical for the function of human HSCs. DROSHA directly recognises and degrades mRNAs in humans HSCs. However, unlike in murine HSCs, the degradation of the MYL9 mRNA alone is not critical for human HSC function. Therefore, DROSHA must be inhibiting other targets and/or has another miRNA-independent function that is essential for safeguarding the pluripotency of human HSCs.