IDH clonal heterogeneity segregates a subgroup of non-1p/19q codeleted gliomas with unfavourable clinical outcome.

Shangyi LuoShiwei ZhuJianlong LiaoYajing ZhangXiaobo HouTao LuoErjie ZhaoJinyuan XuLin PangXin LiangYun XiaoXia Li

Published in: Neuropathology and applied neurobiology (2020)

For the first time, we integrated the clonal status of somatic mutations into cancer genomic classification and highlighted the necessity of considering IDH clonal architectures in glioma precision stratification.

Keyphrases

low grade
copy number
high grade
papillary thyroid
machine learning
deep learning
single cell
wild type
squamous cell carcinoma
randomized controlled trial
gene expression
clinical trial
young adults
genome wide