An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype.

Michael FrickerLing QinStephany Sánchez-OvandoJodie L SimpsonKatherine J BainesCarlos RiverosHayley A ScottLisa G WoodPeter Ab WarkNazanin Z KermaniKian Fan ChungPeter G Gibson

Published in: Allergy (2021)

We demonstrate a pathophysiologically relevant sputum macrophage transcriptomic programme in NA. The finding that there is transcriptional activation of inflammatory programmes in cell types other than neutrophils supports the concept of NA as a specific endotype.

Keyphrases

single cell
cystic fibrosis
rna seq
mycobacterium tuberculosis
pulmonary tuberculosis
adipose tissue
gene expression
lung function
chronic obstructive pulmonary disease
transcription factor
cell therapy
oxidative stress
study protocol
allergic rhinitis
randomized controlled trial
heat stress
heat shock protein