The safety profile and effectiveness of propofol-remifentanil mixtures for total intravenous anesthesia in children.

Oliver N T Bagshaw Jon McCormack Peter M Brooks David Marriott Alistair G Baxter

Published in: Paediatric anaesthesia (2020)

These data demonstrate that effective anesthesia can be administered to pediatric patients undergoing a wide range of procedures using mixtures of propofol and remifentanil. Serious, related, unexpected adverse events requiring intervention had a low incidence and were largely due to predictable effects of the drugs being administered. A ≤5 μg mL-1 remifentanil concentration is associated with proportionately less complications.

Keyphrases

patients undergoing
randomized controlled trial
ionic liquid
risk factors
young adults
systematic review
electronic health record
high dose
big data
drug induced
low dose
machine learning
data analysis
deep learning