IKBKE enhances TMZ-chemoresistance through upregulation of MGMT expression in glioblastoma.

G GuoY SunR HongJ XiongY LuY LiuJ LuZ ZhangC GuoY NanQiang Huang

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)

Our studies suggest that inhibition of IKBKE can enhance the therapeutic effect of TMZ on GBM in vitro and in vivo, providing new research directions and therapeutic targets for the treatment of GBM.

Keyphrases

poor prognosis
cell proliferation
long non coding rna
signaling pathway
combination therapy
replacement therapy
smoking cessation