Changes in Overall Survival over Time for Patients with de novo Metastatic Breast Cancer.
Toshiaki IwaseTushaar Vishal ShrimankerRuben Rodriguez-BautistaOnur SahinAnjali JamesJimin WuYu ShenNaoto Tada UenoPublished in: Cancers (2021)
The purpose of this study was to determine the change in overall survival (OS) for patients with de novo metastatic breast cancer (dnMBC) over time. We conducted a retrospective cohort study with 1981 patients with dnMBC diagnosed between January 1995 and December 2017 at The University of Texas MD Anderson Cancer Center. OS was measured from the date of diagnosis of dnMBC. OS was compared between patients diagnosed during different time periods: 5-year periods and periods defined according to when key agents were approved for clinical use. The median OS was 3.4 years. The 5- and 10-year OS rates improved over time across both types of time periods. A subgroup analysis showed that OS improved significantly over time for the estrogen-receptor-positive/HER2-positive (ER+/HER2+) subtype and exhibited a tendency toward improvement over time for the ER-negative (ER-)/HER2+ subtype. In addition, median OS was significantly longer in patients with non-inflammatory breast cancer (p = 0.02) and patients with ER+ disease, progesterone-receptor-positive disease, HER2+ disease, lower nuclear grade, locoregional therapy, and metastasis to a single organ (all p < 0.0001). These findings showed that OS at 5 and 10 years after diagnosis in patients with dnMBC improved over time. The significant improvements in OS over time for the ER+/HER2+ subtype and the tendency toward improvement for the ER-/HER2+ subtype suggest the contribution of HER2-targeted therapy to survival.
Keyphrases
- estrogen receptor
- metastatic breast cancer
- endoplasmic reticulum
- breast cancer cells
- end stage renal disease
- clinical trial
- chronic kidney disease
- oxidative stress
- ejection fraction
- newly diagnosed
- randomized controlled trial
- molecular dynamics
- free survival
- mesenchymal stem cells
- bone marrow
- smoking cessation
- study protocol
- childhood cancer
- placebo controlled